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| "Saccharin
is the oldest artificial sweetener; it was discovered
in 1879 by Ira Remsen and Constantin Fahlberg of Johns
Hopkins University. Saccharin can be produced in various
ways. Remsen & Fahlberg's original route starts with
toluene, but yields from this starting point are small.
In 1950, an improved synthesis was developed at the Maumee
Chemical Company of Toledo, Ohio. In this synthesis, anthranilic
acid successively reacts with nitrous acid, sulfur dioxide
and chlorine, and then ammonia to yield saccharin. Another
route begins with o-chlorotoluene. (Bungard, 1967).Read
more about Saccharin |
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Saccharin
3D
Molecular Structure using Jmol
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